The Interaction of Human Papilloma Virus Oncoproteins (E۶,E۷) and Retinoblastoma Protein (pRb) in Angiogenesis Regulation

Cervical cancer is a type of cancer that occurs in the squamous cells of the uterus. Different types of Human Papilloma Virus (HPV), a sexual infection, play a key role in endometrial cancer. It has double-stranded DNA with a genome composed of ۸۰۰۰ base pairs and it is classified into two types of low risk and high risk, and it seems that two ۱۶ and ۱۸ high-risk strains are responsible for more than ۷۰% of endometrial cancer cases and they only host those human cells which may not be obvious clinically or they may cause benign and malignant lesions. This type of cancer depends on two E۶, and E۷ oncoproteins that play role in formation of tumor structurally and angiogenesis compared to other important factors that have a significant role in the progression of this type of cancer. The present study aims to investigate the performance of two E۶ and E۷ oncogenes and their inhibitory activity in line with suppressing P۵۳ and PRB and also investigating the role of angiogenesis in the function of these oncogenes

Keywords:

Cervical cancer , HPV , E۶ and E۷ , PRB , Angiogenesis