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Title

“Does Oronasal Administration of Antiseptic Agents Affect on Viral Load in COVID ۱۹ Orthodontic Patients?”: A Systematic Review and Meta-analysis

Year: 1401
COI: JR_ORTHO-17-1_001
Language: EnglishView: 19
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Authors

Arezoo Jahanbin - Professor, Department of Orthodontics, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
Mostafa Entezari - Resident, Department of Orthodontics, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
Erfan Bardideh - Orthodontist

Abstract:

Aim: Droplets and aerosols are the main source of transmission and rapid spread of COVID-۱۹ worldwide. Topical mouthwashes and oronasal irrigation are recommended as ways of preventing airborne transmission to health care professionals. This meta-analysis aimed to assess the changes of COVID ۱۹ viral load after administration of different mouthwashes.Methods: An electronic search was undertaken including the following databases: Medline/PubMed, Web of Science, Scopus, and Embase. Search for grey literature, and hand search for relevant studies was also performed. The quality of included randomized clinical trials (RCTs) were assessed using the Cochrane Collaborations. Afterward, the relevant data from the included studies was extracted. Inverse-variance random-effects meta-analysis was performed to compare the effects of different types of mouthwashes on COVID viral presence.Results: After screening ۱۴۳۷ studies, ۱۰ randomized clinical trials were finally selected. A total of ۸۸۴ patients were assessed in these studies. The meta-analysis revealed the Cyclic Threshold (CT) values increased after the use of mouthwashes (MD=۲.۰۰, ۹۵%CI= ۰.۵۱, ۳.۴۹, P<۰.۰۵). Considering the CT values are inversely correlated to the viral load, the result means the use of mouthwashes decreases the viral load in the saliva. This study also showed that increase of CT values was statistically significant for Povidone Iodine mouthwash (MD=۴.۰۸, ۹۵%CI= ۰.۱۳, ۸.۰۲, P<۰.۰۵); however, Cetylpyridinium Chloride and Chlorhexidine Gluconate mouthwashes non-significantly (P value>۰.۰۵) reduced viral load in the saliva of patients with COVID ۱۹.Conclusion: According to the result of this study, the use of mouthwashes reduces the viral load of saliva in patients with COVID ۱۹. In addition to basic precautions for preventing the transmission of COVID ۱۹, using mouthwashes may be a reasonable way to decrease the risk of disease transmission to medical staff.

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Paper COI Code

This Paper COI Code is JR_ORTHO-17-1_001. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1464477/

How to Cite to This Paper:

If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
Jahanbin, Arezoo and Entezari, Mostafa and Bardideh, Erfan,1401,“Does Oronasal Administration of Antiseptic Agents Affect on Viral Load in COVID ۱۹ Orthodontic Patients?”: A Systematic Review and Meta-analysis,https://civilica.com/doc/1464477

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The specifications of the publisher center of this Paper are as follows:
Type of center: علوم پزشکی
Paper count: 8,321
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COI stands for "CIVILICA Object Identifier". COI is the unique code assigned to articles of Iranian conferences and journals when indexing on the CIVILICA citation database.

The COI is the national code of documents indexed in CIVILICA and is a unique and permanent code. it can always be cited and tracked and assumed as registration confirmation ID.

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