Effects of Vitamin D۳ Fortified Low-fat Dairy Products on Bone Density Measures in Adults with Abdominal Obesity: A Randomized Clinical Trial

Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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تاریخ نمایه سازی: 12 تیر 1401

Abstract:

Background: Bone disease-related fractures constitute a heavy burden on the healthcare systems and economy.Vitamin D is an important regulator of bone health and its deficiency is a global problem. This study aimed to evaluatethe effect of the ۱,۵۰۰ IU nano-encapsulated vitamin D used for fortifying low-fat dairy products (milk and yogurt) onbone health parameters.Methods: This parallel totally blinded, randomized controlled trial was part of the Ultraviolet Intake by NutritionalApproach study and conducted on ۳۰۶ individuals with abdominal obesity. Individuals were randomly assigned tofour groups, including fortified low-fat milk (۱,۵۰۰ IU nano-encapsulated vitamin D۳ per ۲۰۰ g/d), non-fortified low-fatmilk, fortified low-fat yogurt (۱,۵۰۰ IU nano-encapsulated vitamin D۳ per ۱۵۰ g/d), and non-fortified low-fat yogurt,for ۱۰ weeks between January and March ۲۰۱۹. Bone mineral density (BMD) and trabecular bone score (TBS) weremeasured at the baseline and end of the trial. Trabecular bone score and BMD were defined as primary and secondaryoutcomes.Results: There were no significant differences in TBS and BMD between the intervention and control groups at theend of the trial (P>۰.۰۵).Conclusion: This trial demonstrated no significant effect of nano-encapsulated vitamin D fortified milk and yogurt onBMD and TBS. There remains a need for longer-term trials regarding bone health outcomes to establish optimal dosesof fortification.Level of evidence: I

Authors

Payam Sharifan

۱.International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran ۲ Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran ۳

Elahe Hassanzadeh

International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran

Maryam Mohammadi-Bajgiran

International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran

Vahid Reza Dabbagh

Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Elham Aminifar

Student Research Committee, Islamic azad University, Mashhad Branch, Mashhad, Iran

Hamideh Ghazizadeh

International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran- Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Sara Saffar-Soflaei

International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran- Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Susan Darroudi

International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran - Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Davoud Tanbakouchi

Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Mohammad Reza Fazl-Mashhadi

Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran

Ali Ebrahimi-Dabagh

Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran

Mohammad Amin Mohammadi

Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran

Anahid Hemmatpur

Department of Biochemistry, School of Medicine, Shahid Sadoughi University of Medical sciences and health Services, Yazd, Iran

Gordon A. Ferns

Division of Medical Education, Brighton & Sussex Medical School, Falmer, Brighton, Sussex, UK

Habibollah Esmaily

Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Ramin Sadeghi

Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Majid Ghayour-Mobarhan

International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran