miR-۱۸۱-۵p , miR-۱۹-۳p, miR-۱۴۴-۳p , miR-۱۰۱-۳۹.۲, miR-۲۱۸-۵p target autism genes and regulate axon guidance, cAMP and MAPK signalling pathway

Autism spectrum disorder (ASD) is a term used to describe a constellation of Behavioral and mental disorders and social communication defects with the repetitive activity that is lifelong. Studies recently have shown the complex underpinnings of genetic and high heritability for autism. Due to the widespread behavioural symptoms of the disease in patients with neurodevelopmental disorders, it is difficult to diagnose correctly and quickly. Due to the widespread behavioural symptoms of the disease in patients with neurodevelopmental disorders, it is difficult to diagnose correctly and quickly. Accordingly, the use of molecular methods and biomarkers such as microRNAs can be useful in diagnosing autism from other neurodevelopmental disorders. In this study, we used databases to find the microRNAs and their target genes that are most associated with the pathogenesis of ASD. The association between autism and other neurodevelopmental disorders was also examined. According to analyzes, microRNAs, miR-۱۸۱-۵p , miR-۱۹-۳p, miR-۱۴۴-۳p ,miR-۱۰۱-۳۹.۲,miR-۲۱۸-۵p are most associated with autism.

Keywords:

Autism , miR-۱۸۱-۵p , miR-۱۹-۳p , miR-۱۴۴-۳p , miR-۱۰۱-۳۹.۲ , miR-۲۱۸-۵p