Evaluation of the Long-Term Survival in Non-Metastatic Young Breast Cancer Patients in South of Iran

Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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JR_ZUMS-30-141_005

تاریخ نمایه سازی: 25 مرداد 1401

Abstract:

Background and Objective: The lack of breast cancer screening in young women leads to late disease diagnosis and worse outcomes in this age group. This study was designed to evaluate clinicopathological features and long-term outcomes of young breast cancer women in south of Iran. Materials and Methods: This is a retrospective study of breast cancer patients who were pathologically diagnosed during ۲۰۰۵ to ۲۰۱۷. Data from ۲۸۴ breast cancer patients aged ۴۰ years or younger were included in this study. Demographic, clinicopathological properties as well as treatment modalities including type of surgery, adjuvant radiotherapy, and adjuvant or neoadjuvant chemotherapy were recorded and analyzed. Results: Median age of the patients was ۳۶ (range ۲۳-۴۰) years. After a median follow-up of ۶۸ months, ۲۱ patients had died due to the disease, ۵۹ patients were alive with the disease, and ۲۰۴ patients were alive without the disease. The univariate COX regression demonstrated that the disease -free survival (DFS) was significantly low in patients who had undergone breast conservation surgery (BCS) and also patients with higher stages, estrogen/progesterone-negative and human epidermal growth factor receptor ۲-positive (ER-/PR-/HER۲+) status. Low overall survival (OS) was also significantly associated with stage. According to multivariate COX regression, BCS, stages II, III and also young age were independent predictive factors for low DFS. Conclusion: Given the aggressive features and worse outcome of young breast cancer patients, treatment remains tough and screening seems to be required at young age. Further studies are required to find best management and therapeutic protocols for these patients.

Authors

Behnam Kadkhodaei

Dept. of Radiation Oncology, Shiraz University of Medical Sciences, Shiraz, Iran

Ahmad Mosalaei

Dept. of Radiation Oncology, Shiraz University of Medical Sciences, Shiraz, Iran

Shapour Omidvari

Dept. of Radiation Oncology, Shiraz University of Medical Sciences, Shiraz, Iran

Mansour Ansari

Dept. of Radiation Oncology, Shiraz University of Medical Sciences, Shiraz, Iran

Mohammad Mohammadianpanah

Dept. of Radiation Oncology, Shiraz University of Medical Sciences, Shiraz, Iran

Niloofar Ahmadloo

Dept. of Radiation Oncology, Shiraz University of Medical Sciences, Shiraz, Iran

Hamid Nasrollahi

Dept. of Radiation Oncology, Shiraz University of Medical Sciences, Shiraz, Iran

Seyed Hassan Hamedi

Dept. of Radiation Oncology, Shiraz University of Medical Sciences, Shiraz, Iran

Mehdi Shariat

Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Mozhdeh Zamani

Autophagy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

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