Allele Frequency of ۱۵ Autosomal Short Tandem Repeat Loci in Iranian Population with Comparison to Some Other Population

Background: Short tandem repeat (STR) markers are extensively being used forhumanidentification as well as paternity and forensicanalysis of biological evidence.Objectives: The aim of this study was to investigate the allelic frequencies and several forensic and paternity parameters of ۱۵ autosomalshort tandem repeat (STR) loci D۳S۱۳۵۸, D۱۶S۵۳۹۱, D۷S۸۲۰, D۸S۱۱۷۹, D۲۱S۱۱, D۱۸S۵۱, D۵S۸۱۸, D۱۳S۳۱۷, FGA, THO۱, TPOX, CSF۱PO,vWA , D۲S۱۳۳۸, and D۱۹S۴۳۳ in the Iranian population.Methods: Estimation of allelic frequencies and several forensic and paternity parameters of ۱۵ STR loci were performed with theAmpFLSTR Identifilerr kit (Applied Biosystems) for ۲۷۴ unrelated individuals living in Iran.Results: No deviation from Hardy-Weinberg equilibrium was found in any loci studied in this population. Among the ۱۵ STR locianalyzed in the Iranian sample, the most discriminating loci were D۲۱S۱۱, D۲S۱۳۳۸, D۱۹S۴۳۳, D۱۸S۵۱ and FGA with the highest powerof discrimination. The allelic distribution also was compared to ۱۳ other populations including ۳ Iranian population living in Syria,Dubai, the USA and in Fars province and ۸ population from published studies of Azerbaijan, Bolu in Turkey, Morocco, Syria, Iraq,Saudi Arabia, Turkey, East Anatolia, and Pakistan.Conclusions: It was concluded that the population of present study had the least similarity with Azerbyjani (۱۱ loci) and most similaritywith the Iranian population in USA (۱۵ loci).

Keywords:

Allele Frequency , STR , Iran , AmpFLSTR Identifiler