Cholecalciferol therapy; is it the gold standard for vitamin D deficiency and mineral disorders in hemodialysis?

Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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JR_JRE-7-1_009

تاریخ نمایه سازی: 30 مرداد 1401

Abstract:

Introduction: Vitamin D deficiency is frequently observed among dialysis patients. Previous studies suggested that ۵۰ to ۹۰% of end-stage renal disease patients are deficient in vitamin D. In Tunisia, studies regarding hypovitaminosis D in patients on dialysis are not numerous. Actually, many data support the use of native vitamin D in hemodialysis (HD) patients. In Tunisia, using native vitamin D is not part of therapeutic habits of all dialysis centers.Objectives: The aim of this study was to determine the prevalence of vitamin D deficiency in patients with chronic kidney disease stage ۵ undergoing HD and to evaluate the effect of oral cholecalciferol supplementation, in intact parathormone (iPTH), serum calcium and serum phosphorus.Patients and Methods: We conducted a pre-experimental study among HD patients. Monthly oral supplementation with Cholecalciferol, was instituted for six months.Results: Forty-three participants were included. The mean ۲۵-hydroxy vitamin D concentration was ۱۷.۸۹ ng/mL. Vitamin D deficiency was observed in ۸۳.۷% of our patients. We observed a significant increase in ۲۵-hydroxy vitamin D and calcium levels and a significant decline in iPTH levels. No evidence of toxicity, nor severe hypercalcemia or hyperphosphatemia was noted.Conclusion: The supplementation with cholecalciferol seems reasonable and well tolerated in HD patients if reasonable doses are used with regular monitoring.

Authors

Mouna Jerbi

Department of Nephrology, Mongi Slim Hospital, Marsa, Laboratory of Kidney Pathology (LR۰۰SP۰۱) Charles Nicolle Hospital, Faculty of Medicine Tunis, University of Tunis El Manar, Tunis, Tunisia

Hiba Ghabi

La Rabta Hospital, Department of Nephrology, Faculty of Medicine Tunis, University of Tunis El Manar, Tunis, Tunisia

Hanene Gaied

La Rabta Hospital, Department of Nephrology, Faculty of Medicine Tunis, University of Tunis El Manar, Tunis, Tunisia

Fathi Ben Hmida

Department of Nephrology, Charles Nicolle Hospital, Laboratory of Kidney Pathology (LR۰۰SP۰۱) Charles Nicolle Hospital, Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia

Raja Aoudia

Department of Nephrology, Charles Nicolle Hospital, Laboratory of Kidney Pathology (LR۰۰SP۰۱) Charles Nicolle Hospital, Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia

Rim Goucha

Department of Nephrology, Mongi Slim Hospital, Marsa, Laboratory of Kidney Pathology (LR۰۰SP۰۱) Charles Nicolle Hospital, Faculty of Medicine Tunis, University of Tunis El Manar, Tunis, Tunisia