Troponin is a useful marker in clinical decision making in hospitalized patients with COVID-۱۹ infections

BACKGROUND: COVID-۱۹ was introduced by the World Health Organization (WHO) as a global pandemic. The spectrum of symptoms of the disease ranges from a mild cold to death. It has a higher mortality rate in people with a history of comorbidities, including cardiovascular disease (CVD) and can also contribute to cardiac injury. This study was conducted to evaluate the relationship between troponin levels as a cardiac marker and adverse outcomes in this disease.METHODS: The study sample included ۴۳۸ patients hospitalized with COVID-۱۹; however, the troponin data of ۶ patients were not available. The need to be admitted to the intensive care unit (ICU), and death were considered the adverse outcome in patients with COVID-۱۹. Troponin levels were checked in all patients on day ۱ and day ۳ of hospitalization. Multiple logistic regression analysis was performed to determine whether there was an independent association between the adverse outcomes and troponin enzyme in hospitalized patients with COVID-۱۹.RESULTS: The mean age of patients was ۶۱.۲۹ ± ۱۵.۸۴ years. Among the ۴۳۲ patients tested on day ۱ of hospitalization, ۲۴ patients (۵.۶%) tested positive (Troponin ۱), and among the ۳۰۳ patients tested on day ۳, ۱۳ patients (۴.۳%) tested positive (Troponin ۲). Based on our results, Troponin ۱ showed an independent association with both death (۳.۰۰۸ [۹۵%CI = ۱.۰۹۱-۸.۲۹۰]; P = ۰.۰۳۳) and need for ICU admission (۸.۴۹۹ [۹۵%CI = ۳.۳۱۶-۲۱.۷۸۸]; P < ۰.۰۰۱) in multiple logistic regression analysis. Moreover, the status of Troponin ۲ had an independent significant association with both death (۴.۱۵۹ [۹۵%CI = ۱.۱۵۶-۱۴.۹۶۱]; P = ۰.۰۲۹) and ICU admission (۷.۷۹۶ [۹۵%CI = ۱.۹۵۴-۳۱.۰۹۷]; P = ۰.۰۰۴).CONCLUSION: Troponin showed a significant association with adverse outcomes in people who were hospitalized with COVID-۱۹. The serial assessment of this enzyme from the time of hospitalization may improve the clinical decision making of clinicians.

Keywords:

Troponin , COVID-۱۹ , Mortality