Relationship between metabolic syndrome and angiographic severity of coronary artery disease

BACKGROUND: There are a few literature data on the correlation between metabolic syndrome (MetS) and coronary disease among Iranian population. This study aimed to find relationship between MetS and severity of coronary artery disease (CAD) in presence of diabetes. METHODS: Total of ۱۹۲ patients were consecutively enrolled in the study who were admitted to coronary care unit because of acute coronary syndrome (ACS) and then underwent coronary angiography. MetS was defined by Iranian criteria. A coronary atherosclerosis score was used to quantify the extent of atherosclerotic involvement. The relationship between MetS and angiographic CAD severity or clinical presentation was compared between them after adjusting for diabetes. RESULTS: Individuals with MetS (n = ۱۲۵) had a higher prevalence of ST-elevation myocardial infarction (۷۱% vs ۳۰%, P < ۰.۰۰۱), multi-vessel disease (۵۰% vs. ۳۴%, P = ۰.۰۰۳), decreased ejection fraction (P = ۰.۰۰۱) and more severe angiographic stenosis based on both modified Gensini (P = ۰.۰۸۱) and syntax (P = ۰.۰۰۸) scores, compared to those without MetS. Syntax score showed statistically significant difference between two groups before (P = ۰.۰۲۱) and after adjustment for diabetes (P = ۰.۰۰۵). CONCLUSION: MetS was related to the severity of CAD both clinically and by angiographic scores but diabetes was a challenging factor and may independently increase the severity of CAD.   

Keywords:

Metabolic Syndrome , Angiography , Severity , Coronary Artery Disease