The Association between Metabolic Syndrome and the Consumption of some Supplements

Background: Beneficial effects of vitamins and dietary supplements in the prevention and treatment of metabolic syndrome (MS) are controversial. This study aims to evaluate the association between dietary supplements intake and MS. Methods: This analytical cross-sectional analysis was conducted on ۹۵۳۹ people aged ۳۵-۷۰ years who participated in the recruitment phase of Shahedieh Cohort Study in Yazd-Iran (May ۲۰۱۵ to September ۲۰۱۷). The consumption of supplements, such as multivitamin-mineral, multivitamin, calcium-D, calcium, vitamin D, folic acid, omega ۳, iron, and zinc were asked in the study. the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) criteria used for defining MS. Results: ۴۷۸۵ (۵۰.۲%) men and ۴۷۵۴ (۴۹.۸%) women with mean age of ۴۷.۶۴ ± ۹.۶۰ years participated in this study. The prevalence of MS was ۲۹۰۱ (۳۰.۴۱%). The participants with MS were significantly different in consuming supplements, such as Calcium-D (P < ۰.۰۰۱), Calcium (P < ۰.۰۰۱), Calcium-D or Calcium products (P = ۰.۰۰۱), vitamin D; injection (P = ۰.۰۱۷) and vitamin D orally or injection (P = ۰.۰۰۵), Omega ۳, fish oil (P = ۰.۰۰۱), and at least one supplement intake (P = ۰.۰۰۱). However, the relationship between MS and supplement consumption was not significant after adjusting for covariates in the multivariate regression model. Conclusion: Multiple factors may be responsible for the high prevalence of MS. It seems that a known supplement may not be the pathologic factor in the MS

Keywords:

Metabolic syndrome , Oxidative stress , Vitamins