Preliminary Dosimetry Study of ۴۶Sc-AATS for Human Based on Biodistribution Data in wild-type mice

Introduction:Thiosemicabazone and theirmetl complexes are active biological compounds that have antibactrial , antifungal and antitumor properties.for this perpose, in this article ,the labeling of acetyl acetate bis thiosemicarbazone complex by Scandium-۴۶ isotope has been done.Methods: Scandium-۴۶ was produced in the Tehran reaserch reactor by bombarding Sc-۴۵ by thermal neutron flux of ( ۳.۵ . ۱۰۱۳ n.cm.s-۱)during the ۴۵ Sc(n,γ) ۴۶ Sc reaction.then AATS complex was synthesized through chemical processes and after labeling the complex by Scandium-۴۶, the radiochemical purity was investigated by thin layer chromatography (TLC) and radiochromatography (ITLC),and finally its biodistribution was investigated after the injection of the labeled complex into mice.Results:the preparation of radionuclide with radiochemical purity above(>۹۰%) has happened and radiochemical purity of the acetyl acetate bis thiosemicarbazone complex (AATS) labeled by Sc-۴۶ has been very favorable >۹۸% and the study of the biodistribution of AATS-۴۶Sc complex was conducted within ۴۸ hours and noticeableDDiscuss:as seen, AATS has been successfully labeled by ۴۶ Sc isotope and its absrption mechanism has been very good, and it indicates that by labeling the above compound with Scandium-۴۷

Keywords:

Thiosemicabazone , Scandium-۴۶ , labeling , biodistribution