In-silico study of rs۳۰۲۵۰۴۰ and hsa-mir-۱۹۹a-۵p single nucleotide polymorphisms related to VEGFA gene in patients with gastric cancer

Backgrounds: In Iran, one of the most common malignancies is gastric cancer so the study ofbiomarkers of this disease is of great importance. The angiogenic factor VEGF has beeninvestigated the most. It's linked to neoplastic disease and lymph node metastases. Levels beyonda certain threshold were linked to a poor prognosis and reduced survival rates.Materials and Methods: A gene named is one of the genes linked with this cancer. MicroRNAslinked to this gene were discovered using the miRNA SNP database. A single nucleotidepolymorphism called Rs۳۰۲۵۰۴۰ was discovered. The DAVID database of this microRNApicked the corresponding signal signals for further analysis.Results: For OC, ۸۵۰ genes have been discovered. VEGFA genes were shown to have a highlevel of expression, while has-mir-۱۹۹a-۵p had up-expression examination of OC signalingpathways, as well as the influence of this Mir on gene targets.Conclusion: These findings imply that VEGF۱ could be a potential gene therapy target forgastric cancer. Blocking VEGF expression in GC cells induces apoptosis, which may provide anovel treatment approach.

Keywords:

Stomach cancer , Bioinformatics , VEGFA gene , MicroRNA (has mir ۱۹۹a ۵p) , Single nucleotide polymorphism (rs۳۰۲۵۰۴۰)