Alignment and phylogenetic tree analysis of some corona and influenza type-A viruses based on nucleocapsid protein sequences

Backgrounds: The nucleocapsid (N) proteins of viruses, as with most enveloped viruses, havereceived less attention than the surface glycoproteins and generally have been perceived to be oflesser concern. Interest in this class of proteins, however, has been stimulated in recent yearsespecially in this pandemic age. The nucleocapsid phosphoprotein of the severe acute respiratorysyndrome coronavirus (SARS-CoV N protein) packages the viral genome into a helicalribonucleocapsid (RNP) and plays a fundamental role during viral self-assembly.Materials and Methods: In this article by using multalin software and their phylogenetic tree byneighbor-joining method protein sequence of ۱۰ subfamily of corona viruses and four subfamilyof influenza A viruses from National Center for Biotechnology Information GenBank wereanalyzed.Results: Alignment showed low similarity in consensus. The phylogenic tree displayed thatinfluenza and corona virus have a common ancestor and delta corona virus subfamily has moredifference compare to other types of corona virus.Conclusion: We discussed their relativity and how they change during the mutations that theyhad. This high number of mutations and variations in sequences can provide resistance tovaccine and drugs.

Keywords:

Corona virus , Influenza virus , Nucleocapsid , Pandemic , Alignment