The role of proteases in the invasion of SARS-CoV-۲ virus into human host cells

Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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JR_JCBIOR-2-1_007

تاریخ نمایه سازی: 9 آبان 1401

Abstract:

The new coronavirus, which originally broke out in Wuhan, China, in December ۲۰۱۹, increase quicklyaround the world, causing a pandemic all over the world. The virus uses its spike protein to enter thehuman host cells. Protein S binds to the angiotensin-converting enzyme II (ACE۲) receptor and entersthe host cell. For the more successful binding, several proteases facilitate and optimize this binding, themost important of which are transmembrane protease serine ۲ (TMPRSS۲), furin, and cathepsin Lproteases. After binding of protein S to the ACE۲ receptor, cleavage of protein S is required formembrane fusion by protein S, which causes viral entry into host cells. This proteolytic activity may becathepsin L-dependent and occurs with changes in pH in cell endosomes, or it may occur through serineproteases activity at the surface of the host cell membrane or within vesicles. Finally, the cell becomesinfected with the virus. Several studies have tried to reduce the rate of viral infection by using inhibitorsof these proteases.

Authors

Maryam Saeidi

Department of Cellular and Molecular, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

Fatemeh Rouhollah

Department of Cellular and Molecular, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran