The Role of Connective Tissue Genomics in Ascending Aortic Dissection: A Marfan Syndrome Scenario

Background: Aortic dissection is a rare yet life threating condition with some already discovered risk factors namely hypertension, connective tissue disorders such as Marfan syndrome (MFS), cocaine abuse and cigarette smoking.Case report: In this article we would like to present a case of MFS who presented with severe chest pain and undergone Bentall surgery due to aortic dissection and aneurysm.Conclusion: Although many risk factors and preventive measures are already investigated, there is no definite method to avoid its occurrence in genetically predisposed patients such as MFS. Patient-specific models utilizing embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC) may offer some advantages.

Keywords:

Aortic Dissection , Marfan Syndrome , Induced Pluripotent Stem Cell , Embryonic Stem Cell