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Effects of Dexmedetomidine on Clinical Outcomes and Renal Function after CABG

Publish Year: 1400
Type: Journal paper
Language: English
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Document National Code:

JR_SBMU-6-1_002

Index date: 31 October 2022

Effects of Dexmedetomidine on Clinical Outcomes and Renal Function after CABG abstract

Background: This study was carried out to determine the effects ofdexmedetomidine on clinical outcomes and renal function after coronary arterybypass grafting (CABG) to address the increased rate of CABG? and theimportance of modification in stress responses and control of adverse effects onrenal function and with the aim of cost reduction.Materials and Methods: This double-blind randomized clinical trial wascarried out with the participation of 129 subjects under elective CABG in RajaeiHeart Center, Tehran, Iran in 2017. Patients were randomly assigned to fourgroups with simple randomization including one placebo (normal salineinfusion) group and three dexmedetomidine groups; 0.5 μg/kg/h on CPB, 0.5μg/kg/h in 24 hours, and 0.75 μg/kg/h in 24 hours. The blood pressure, bloodurea nitrogen (BUN), serum creatinine, transfused blood volume, urine volume,and hemofiltration on pump and lactate were assessed at different time intervals.Results: Results showed more stability especially in central venous pressure(CVP) (p=0.001) and systolic blood pressure (p=0.006) in the groupsreceiving dexmedetomidine 0.75 μg/kg/h per 24 hours. But diastolic bloodpressure and heart rate were the same across the groups (p>0.05). All othervariables including hepatic and renal function tests were the same across thegroups (P>0.05).Conclusion: Overall, according to the obtained results in the current study, itmay be concluded that dexmedetomidine would have some promising effectson hemodynamic stability but there are no obvious renoprotective effects forthis medication.

Effects of Dexmedetomidine on Clinical Outcomes and Renal Function after CABG Keywords:

Coronary Artery Bypass Graft , Dexmedetomidine , Renal Function

Effects of Dexmedetomidine on Clinical Outcomes and Renal Function after CABG authors

Mehdi Rahab

Effects of Dexmedetomidine on Clinical Outcomes and RenalFunction after CABG

Evaz Heydarpour

Rajaie Cardiovascular, Medical and Research Center, Tehran, Iran

Ziae Totonchi

Rajaie Cardiovascular, Medical and Research Center, Tehran, Iran

Naser Karchoueian

Department of Cardiovascular Surgery, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Sam Zeraatiannejad Davani

Department of General Surgery, School of Medicine, Hazrat-e Rasool General Hospital, Iran University ofMedical Sciences, Tehran, Iran

Mehrdad Mesbah Kiaei

Department of Anesthesiology, School of Medicine, Hasheminejad Kidney Center, Iran University of MedicalSciences, Tehran, Iran