A Completely ۳dimensional Simulation of Urine Concentrating Mechanism in Functional Unit of Rat Outer Medulla

The urine formation and excretion system has long been of interest for mathematicians and physiologists. In current study, a novel three dimensional approach has been utilized for modeling urine concentrating mechanism in rat renal outer medulla which is essentially focused on demonstrating the significance of ۳-D tubules architecture. The model equations are based on mass, momentum and species transport equations in ۳ spatial dimensions as well as standard expressions for solutes and water transtubular equations. Numerical results are completely consistent with tissue slice experiments and even the model has predicted more coricomedullary osmolality gradient than previous equivalent ۱-D simulations.

Keywords:

۳-D modeling , Renal , Outer medulla , Tubules architecture , Urine concentrating mechanism