The Study of Age and Sex in Midterm Survival of the Patients with Cerebral Venous Sinus Thrombosis

Background and Aim: Cerebral venous sinus thrombosis (CVST) is a rare clinical cause of stroke that can have high incidence in young adults. Most of patients with CVST are discharged with favorable outcome; However, delayed diagnosis of CVST could lead to considerable morbidity and mortality. Materials and Methods: This retrospective study recruited CVST patients. Patients were identified through ICD-۱۰ coding system with diagnostic codes of G۰۸ for “intracranial and intraspinal phlebitis and thrombophlebitis”. All-cause mortality was defined to any cause of death relevant or irrelevant to CVST. Survival curves (Kaplan-Meier) were obtained using data of death as the end point outcome. Cox proportional-hazards regression analysis was used to model the time of death data to identify possible predictors of mortality. Results: Total of the recruited patients was ۳۰۱. Mean hospital stay in CVST-related mortality patients was significantly longer than alive patients (P=۰.۰۱۹). Cox proportional hazard model showed that age was considered as a significant risk factor for survival function (HR=۱.۰۵۶, ۹۵%CI: ۱.۰۳۷-۱.۰۷۵). Mortality was significantly higher in >۴۵ age group in comparison to <۴۵ group (HR=۴.۹۹, ۹۵%CI: ۲.۵۰-۹.۹۴, P<۰.۰۰۱). Patients with recurrent CVT had higher risk of mortality in comparison patients without recurrent CVT (HR=۹.۱۴, ۹۵%CI:۴.۷۰-۱۷.۸۹, P<۰.۰۰۱). In addition, there was statistically higher risk of mortality in patients with DVT (HR=۸.۹۷, ۹۵%CI: ۴.۳۲-۱۸.۶۱, P<۰.۰۰۱). Conclusion: In current study, extreme age was determinant of midterm prognosis. Further, this study suggested that if CVST is appropriately diagnosed and treated in early stages and also early mortality is prevented, midterm and probably long-term prognosis is not dismal.

Keywords:

Age , Cerebral venous sinus thrombosis , Midterm survival , Mortality