Human Amniotic Membrane Wrapping of the Ulnar Nerve During Cubital Tunnel Surgery Reduces Recurrence of Symptoms
Publish place: The Archives of Bone and Joint Surgery، Vol: 10، Issue: 11
Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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JR_TABO-10-11_006
تاریخ نمایه سازی: 24 آبان 1401
Abstract:
Background: Compare the recurrence rate of paresthesias in patients undergoing primary cubital tunnel surgery inthose with and without wrapping of the ulnar nerve with the human amniotic membrane (HAM).Methods: A retrospective investigation of patients undergoing primary cubital tunnel surgery with a minimum۹۰-day follow-up was performed. Patients were excluded if the nerve was wrapped using another material, associated traumatic injury,simultaneous Guyon’s canal release, or revision procedures. Failure was defined as those patients who experiencedinitial complete resolution of symptoms (paresthesias) but then developed recurrence of paresthesias.Results: A total of ۵۷ controls (CON) and ۲۱ treated with HAM met our inclusion criteria. There was a difference inthe mean age of CON (۴۸.۴ ± ۱۳.۵ years) and HAM (۳۰.۶ ± ۱۵) (P< ۰.۰۰۰۱). There was no difference in gender mix(P=۰.۴), the severity of symptoms (P=۰.۱۳), and length of follow-up (P=۰.۰۸۴). None of ۲۱ (۰%) treated with HAMdeveloped recurrence of symptoms compared to ۱۱ of ۵۷ (۱۹.۳%) (P=۰.۰۳) (CON). Using a multivariate regressionmodel adjusted for age and procedure type, CON was ۲۴.۴ (۹۵% CI=۱.۲۶-۵۰۰, P=۰.۰۳۴۸) times higher risk than HAMof developing a recurrence of symptoms.Conclusion: The HAM wrapping used in primary cubital tunnel surgery significantly reduced recurrence rates ofparesthesias. Further prospective studies with randomization should be carried out to better understand the role HAMcan play in cubital tunnel surgery.Level of evidence: III
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Authors
Raffy Mirzayan
۱ Kaiser Permanente Southern California, Baldwin Park, CA, USA ۲ USC Keck School of Medicine, Los Angeles, CA, USA
Franco Russo
USC Keck School of Medicine, Los Angeles, CA, USA
Su-Jau Yang
Kaiser Permanente Southern California, Pasadena, CA
Nikko Lowe
Kaiser Permanente Southern California, Baldwin Park, CA, USA
Christopher Shean
Kaiser Permanente Southern California, Baldwin Park, CA, USA
Neil Harness
Kaiser Permanente Southern California, Anaheim, CA, USA