Primary Signet Ring Adenocarcinoma of the Lung in a ۳۴-Year-Old Nonsmoking Man
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JKMU-28-6_011
تاریخ نمایه سازی: 19 دی 1401
Abstract:
Background: Pulmonary carcinoma is a burdensome malignancy that has the third rank in prevalence among other cancers and is the leading cause of death in patients with cancer diagnosis. Signet ring morphology is encountered commonly in many sites like stomach, bladder, gallbladder and etc. Primary signet ring adenocarcinoma of the lung is a rare phenomenon, including about ۵% of all surgically removed pulmonary adenocarcinoma. It should be distinguished from metastatic tumors.Case presentation: a ۳۴-year-old nonsmoker man who referred to Babol Rohani Hospital with a one-month history of nonproductive cough. Biopsy with CT scan guidance from ground-glass opacities of the left lung revealed neoplastic cells with signet ring appearance infiltrating lung parenchyma. Immunohistochemistry (IHC) study revealed positivity of neoplastic cells for AE۱/AE۳, CK۷, TTF-۱ and negativity for CK۲۰, CDX۲, and CD۶۸.Conclusion: The signet ring feature of pulmonary adenocarcinoma has shorter survival, therefore, it is associated with poor prognosis. Immunohistochemistry (IHC) techniques provide the ability to originate tumor cells in these conditions.
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Authors
Akramossadat Hosseini
Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran & Clinical Research Development Center, Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, Iran
Zeinab Vosough
Pathology department, Babol University of Medical Sciences, Babol, Iran
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