Effects of Boswellia serrata on Improvement of Memory Impairment in Patients with Mild Cognitive Impairment: A Double-blind, Randomized, Placebo-controlled Study
Publish Year: 1399
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JKMU-27-4_007
تاریخ نمایه سازی: 19 دی 1401
Abstract:
Background: Mild cognitive impairment (MCI) is the stage between the expected cognitive decline of normal aging and the more serious decline of dementia. In the present study, the effect of Boswellia serrata (BS) on improvement of memory impairment in patients with MCI was investigated. Methods: In this single-center randomized double-blind placebo-controlled clinical trial study, ۱۱۸ patients with mild cognitive impairment (MCI) were included and randomly divided into two groups (case and control). Control group (n=۵۹) received BS ۳۰۰ mg/kg body weight twice a day and control group (n=۵۹) received placebo for a period of three and six months. Montreal Cognitive Assessment (MoCA) test for detecting cognitive impairment was done at baseline, three and six months after the intervention. Results: A significant difference was reported in the MoCA mean score between the groups after three months (۲۴.۶۴ vs. ۲۲.۸۳) and six months of the intervention (۲۵.۲۲ vs. ۲۲.۷). Memory item had the greatest impact on the average final score (P≤۰.۰۰۰۱). Conclusion: BS has a significant effect on the improvement of memory impairment in patients with MCI. Further studies are required with higher doses of BS and longer duration of treatment to assess the effects of BS on memory of patients with MCI.
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Authors
Soheila Rezakhani
Assistant Professor, Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Ir
Behnaz Sedighi
Associate Professor, Neurology Research Center, Kerman University of Medical Sciences, Kerman, Iran
Abbas Pardakhty
Professor, Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
Kaveh Shafiee
Assistant Professor, Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
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