Prognostic and Predictive Clinical, Pathological and Molecular Markers for Oral Squamous Cell Carcinoma: review of articles

Approximately ۹۰% of all head and neck malignancies and ۹۴% of oral malignancies are squamous cell carcinoma (SCC). Tobacco smoking is considered as the most important causative agent for SCC. Despite aggressive and multidisciplinary treatment approaches, there has been no significant improvement in ۵-year survival over the past ۲۰ years. Several prognostic and predictive clinical, pathological and molecular factors have been introduced for SCC. We herein review some of these prognostic factors.