Antimicrobial Resistance Pattern of Escherichia Coli Isolated From Patients With Urinary Tract Infection in Tehran, Iran, in ۲۰۲۱

Background and aims: Urinary tract infections (UTIs) are intense public health problems and are precipitated by a variety of pathogens. This study was performed to determine the frequency of bacterial agents of UTIs and the antibiotic resistance pattern of Escherichia coli in urinary culture samples of patients at Shahid Ashrafi Esfahani hospital in Tehran, Iran. Methods: A cross-sectional study was conducted on all urinary tract cultures from January ۲۰۲۱ to January ۲۰۲۲ at Shahid Ashrafi Esfahani hospital in Tehran, Iran. Urine culture and antimicrobial susceptibility tests were performed according to Clinical and Laboratory Standards Institute (CLSI) guidelines. Statistical analyses were performed by appropriate descriptive and inferential tests such as the chi-square test using Stata version ۱۷, and the level of significance was set at ۰.۰۵. Results: The mean age of patients with E. coli was ۵۰.۲ ± ۱.۸ (confidence interval = ۴۶.۶-۵۳.۸) years, and their age range was between ۶-۸۷ years. The highest prevalence of infection occurred in men over ۶۰ years of age and in women aged ۴۰-۶۰ years. Further, the highest resistance and the highest sensitivity were related to ceftazidime (CAZ) and cefotaxime (CTX), respectively. Conclusion: In this study, the highest resistance and sensitivity belonged to CAZ and CTX, respectively. In addition, CTX is the primary antibiotic prescribed to deal with UTIs in medical practice.

Keywords:

Antimicrobial resistance pattern , Escherichia coli , urinary tract infection