Formulation, microscopic and instrumental fingerprinting analysis of a multi-ingredients traditional Persian medicine product, Coriander Triphala

Background and aims: Today, due to the increasing use of natural and traditional medicinal products, control and standardization of herbal and traditional medicinal products is very important. As most of the traditional medicinal plants are not scientifically validated, scientific evaluation along with traditional knowledge is essential to obtain effective drugs with significant control over the quality of the product for commercial purpose. In traditional Persian medicine, various forms of medicine including one or a combination of several drugs are mentioned. Coriander Triphala widely prescribed as a purgative, gastrointestinal and mental tonic. Despite the widespread use of this drug, no significant control or standardization and documented pharmacognosy studies have been performed on it. Therefore this study is developed for this purpose. Methods: In this study, the traditional form of Coriander Triphala was prepared based on the pharmaceutics points mentioned in traditional medicine texts and quality control and pharmacognostic studies were performed. The associated fingerprints were performed by gas chromatography–mass spectrometry (GC-MS), and then one of the main components of the product was determined by as gas chromatography-flame ionization detector (GC-FID). Results: The spectrum of essential oils of Coriander Triphala and Coriander had ۵۹.۱۹% and ۷۵.۳۴% linalool, respectively. The microbial assay showed no undesirable results. The IR spectrum of Coriander Triphala at first day and ۴۰ days later differed by ۲%. Conclusion: Standardization of the product using GC-FID indicates the presence of ۰.۱۷۲ μg linalool in ۱۰۰ g the Coriander Triphala product.

Keywords:

Traditional Persian medicine , Coriander Triphala , Linalool , GC-MS , GC-FID