Voltammetric Determination of Famotidine Using a Bilayer of Electrodeposited Gold Nanodendrites and Mercapto-propanioc Acid

Due to vital essence of medicine dosage monitoring within therapeutic range, a simple, rapid, high performance, sensitive and environmentally friendly electrochemical sensor was designed and used to diagnosis low concentrations of famotidine, a histamine-۲ blocker, at pharmaceutical products and biological fluids. In this work, a simple, fast response and efficient voltammetic sensor was designed by using the functionalized dendrite-like gold nanostructures with ۳-mercapto-propanioc acid (۳-MPA/Au-DNSs). Electrochemical studies confirmed well the efficiency of the surface modified glassy carbon electrode (GCE) with ۳-MPA/Au-DNSs on amplification of response signal in presence of famotidine in an applicable linear concentration range of ۳.۰ × ۱۰−۷–۱.۰ × ۱۰−۵ M. The limit of detection was evaluated to be ۳.۳۳ × ۱۰−۸ M (for S/N=۳) under the optimum conditions. The modified GCE with ۳-MPA/Au-DNSs was successfully applied in determination of famotidine in real samples such as human serum and pharmaceuticals with recoveries of ۱۰۴.۸ % and ۱۰۰.۹۰%, respectively.

Keywords:

Famotidine , Dendrite-like gold nanostructures , Electrochemical sensor , Serum sample