The Relationship between Insulin Resistance and Micronutrient Intake in Polycystic Ovary Syndrome Subgroups

Background: Polycystic ovary syndrome (PCOS) is with oxidative stress in women of reproductive age. Oxidative stress is an important factor in the development of insulin resistance. Some micronutrients are also linked to oxidative stress. The aim of this study was to determine the relationship between insulin resistance and micronutrient intake in PCOS subgroups. Methods: This case-control study was performed on ۱۵۱ PCOS. They were divided into four groups according to the Rotterdam diagnostic criteria: D = ۳۷, C = ۴۰, B = ۳۳, A = ۴۱ and ۳۱ women were also in the control group and did not have this syndrome. Micronutrient food intake was assessed with a ۱۶۸-item FFQ feed frequency questionnaire. Insulin resistance was diagnosed with HOMA-IR index (Cut off> ۲.۵). The data were analyzed with SPSS ۲۲ using Kruskal Wallis (KW), Spearman, and Chi-square tests. Results: The mean age of participants was ۲۸.۵۳ years. There was a significant relationship between the HOMA-IR and some dietary components (selenium depletion in group A, zinc depletion, vitamin D, and vitamin E in group D, and vitamin D and vitamin E depletion in control group) (P < ۰.۰۵). There was no relationship between subgroups B and C. Conclusion: Due to the significant relationship between insulin resistance indices, increasing the dietary intake of zinc, selenium, vitamin D, and vitamin E in women with PCOS, as well as increasing the dietary intake of these micronutrients in improving the physical health and fertility parameters of these people is recommended.

Keywords:

Micronutrient intake , Polycystic ovary syndrome , Insulin resistance