Antibiotic Susceptibility Patterns in the NICU of Ghaem Hospital of Mashhad

Background and Aims: Neonatal sepsis is considered a clinical syndrome characterized by signs and symptoms of infection associated with positive blood culture. The present study investigates the rate of sensitivity and resistance to antibiotics in neonates with definite sepsis. Materials and Methods: This cross-sectional study was conducted on ۲۶۸ neonates with definitive sepsis (positive blood culture with clinical signs of infection) hospitalized in the NICU of Ghaem Hospital of Mashhad, from ۲۰۰۸ to ۲۰۱۸. To investigate the antibiotic susceptibility pattern, identifying microorganism and antibiogram tests was performed according to the standard microbiological method. The data were collected through a questionnaire designed by the researchers. It included neonates’ characteristics, types of microorganisms in neonatal unite, and sensitivity and resistance to neonatal sepsis’s common microorganism. Results: Based on the results, Klebsiella showed sensitivity to norfloxacin (۱۰۰%), ciprofloxacin (۱۰۰%), meropenem (۱۰۰%), imipenem (۹۴%), co-trimoxazole (۷۳%), and vancomycin (۶۷%). Similarly, Enterobacter showed ۱۰۰% sensitivity to ciprofloxacin, meropenem, norfloxacin, and high sensitivity to imipenem (۹۴%) and co-trimoxazole (۸۳%). Acinetobacter turned out to be sensitive to co-trimoxazole and norfloxacin (both of them were ۶۷%) and to amikacin in ۳۳% of the cases. E. coli was sensitive to imipenem (۸۳.۳۳%), ciprofloxacin (۸۰%), and ceftazidime (۷۱.۴۳%). Finally, staphylococcus coagulase negative was sensitive to piperacillin in ۱۰۰%, vancomycin in ۹۶.۶۷%, and imipenem in ۷۱.۴۳% of the cases. Conclusions: The findings of the present study suggest that high-sensitivity drugs for the treatment of definite neonatal sepsis are Meropenem(Klebsiella and E. coli), Enterobacter (Ampicilin), acinetobacter(Imipenem) and staphylococcus coagulase negative (vancomycin).

Keywords:

Antibiotics , Blood culture , Infections , Infant , Sepsis , عفونت مشخص , سپسیس , نوزادان , آنتی بیوتیک , آنتی بیوگرام , کشت خون