Schiff and semi-carbon base metal complexesfor biomedical and related applications: A review

Schiff bases are versatile organic compounds which are widely used and synthesized by condensation reaction ofdifferent amino compound with aldehydes or ketones known as imine. Schiff base ligands are considered asprivileged ligands as they are simply synthesized by condensation. They show broad range of application in medicine,pharmacy, coordination chemistry, biological activities, industries, food packages, dyes, and polymer and also used asan O۲ detector. Semicarbazone is an imine derivative which is derived from condensation of semicarbazide andsuitable aldehyde and ketone. Imine ligand–containing transition metal complexes such as copper, zinc, and cadmiumhave shown to be excellent precursors for synthesis of metal or metal chalcogenide nanoparticles. In recent years, theresearchers have attracted enormous attention toward Schiff bases, semicarbazones, thiosemicarbazones, and theirmetal complexes owing to numerous applications in pharmacology such as antiviral, antifungal, antimicrobial,antimalarial, antituberculosis, anticancer, anti-HIV, catalytic application in oxidation of organic compounds, andnanotechnology. In this review, we summarize the synthesis, structural, biological, and catalytic application of Schiffbases as well as their metal complexes

Keywords:

component , Schiff base , Semicarbazone , Metal complexes , Biological/biomedical activities