Metabolic syndrome is negatively associated with trabecular bone score and bone mineral density in normal weight adults with central obesity

Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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JR_RCM-10-2_002

تاریخ نمایه سازی: 27 خرداد 1402

Abstract:

Introduction: Metabolic syndrome (MetS) is comprised of a clustering of various cardiovascular risk factors that can also affect bone health. We aimed the associations between MetS and bone mineral density (BMD) and trabecular bone score (TBS) in subjects with abdominal adiposity.Methods: Individuals with body mass index less than ۲۵ kg/m۲ were enrolled from the SUVINA study and allocated into two groups according criteria of IDF for metabolic syndrome. TBS T-score and Z/T score of fore skeletal region were measured using dual-energy X-ray absorptiometry (DXA). SPSS software was used for statistical analysis and p value ۰<۰.۰۵ was considered significant.Results: DXA measurements were made in ۲۰۱ participants, of whom ۷۵ had MetS and ۱۲۶ did not. Scores related to the neck of femur and total femur, radius Z-score and TBST-score were lower in subjects with MetS (all P<۰.۰۵). Subjects with FBG≥۱۰۰ had lower TBST-score (p < ۰.۰۵). SBP≥۱۳۰ and DBP≥۸۵ in subjects, led to the lower TBST-score, and lumbar T-score (both P < ۰.۰۵). Subjects with (LDL-C≥۱۶۰ mg/dl) had lower TBST-score, neck of femur Z score, and total femur T/Z scores (all P < ۰.۰۵). TBST-score and scores related to neck of femur, and total femur were lower in participants with serum cholesterol≥۲۰۰ mg/dl (P < ۰.۰۵).Conclusion: MetS is negatively associated with TBS and BMD scores. Higher levels of LDL-C and cholesterol were the most associated factors related to TBST-score decrease. The neck of femur was the most vulnerable skeletal against the MetS components increment.

Authors

Susan Darroudi

International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran

Payam Sharifan

Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Mahsa Rastegar Moghaddam Poorbagher

Department of Biology, Mashhad Branch, Islamic Azad university, Mashhad, Iran

Maryam Mohamadi Bajgiran

International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran

Sara Saffar Soflaei

International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.

Hamideh Ghazizadeh

International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran

habibollah esmaily

Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Niloofar Shabani

Department of Biostatistics, School of Health, Tehran University of Medical Sciences, Tehran, Iran

Ramin Sadeghi

Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Vahid Reza Dabbagh Kakhki

Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Ali Ebrahimi Dabbagh

Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran

Mohammad Amin Mohammadi

Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran

Mohammad Amin Mohammadi

Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran

sara Moazedi

Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran

Mahdi Rafiee

Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

reza Assaran Darban

Department of Biology, Mashhad Branch, Islamic Azad university, Mashhad, Iran ۵. Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Gordon A. Ferns

Department of Medical Education, Brighton and Sussex Medical School, Falmer, Brighton, UK.

Mohsen Mohebati

Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

majid Ghayour

International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran