Falcaria vulgaris L. hydroalcoholic extract protects against harmful effects of mercuric chloride on the rat kidney

Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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JR_AJP-13-4_009

تاریخ نمایه سازی: 14 تیر 1402

Abstract:

Objective: Mercuric chloride (Merc; HgCl۲) is toxic to humans and animals and contributes to environmental pollution, which usually results in nerve and systemic harm to different organs. Falcaria vulgaris (FV) is a medicinal plant rich in antioxidants. This research aimed to assess the FV hydroalcoholic extract effects on kidney toxicity induced by Merc.Materials and Methods: Forty-eight male rats were divided into eight groups: the control group: received saline; the Merc group: received ۰.۵ ml/day of ۰.۵ ppm aqueous Merc; FV۱, ۲, and ۳ groups: received ۵۰, ۱۰۰, ۱۵۰ mg/kg FV, respectively; and Merc + FV۱, ۲, and ۳ groups: received Merc and FV at three doses. The administration period was ۱۴-days. Subsequently, kidneys and sera were cumulated from each group for the analysis. Samples were analyzed via hematoxylin-eosin staining and biochemical tests.Results: The rats that received Merc displayed significant decrement in the kidney index, the diameter of renal corpuscles, total antioxidant capacity levels, superoxide dismutase activity (all, p<۰.۰۱), and ۱۵۰ mg/kg FV mitigated these outcomes (all, p<۰.۰۵). Urea, creatinine, nitric oxide, and the level of apoptosis revealed a significant increment in the kidney of the rats that received Merc (all, p<۰.۰۱), and ۱۵۰ mg/kg FV decreased these results. Furthermore, FV ameliorated histological changes induced by Merc (all, p<۰.۰۵). Conclusion: The FV hydroalcoholic extract protects the kidneys against Merc-induced nephrotoxicity. Antioxidant and anti-apoptotic FV hydroalcoholic extract properties were involved in this healing effect.

Authors

Ali Ghanbari

Department of Anatomical Sciences, Kermanshah University of Medical Sciences, School of Medicine, Kermanshah, Iran

Cyrus Jalili

Department of Anatomical Sciences, Kermanshah University of Medical Sciences, School of Medicine, Kermanshah, Iran

Amir Abdolmaleki

Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

Mohsen Zhaleh

Department of Anatomical Sciences, Kermanshah University of Medical Sciences, School of Medicine, Kermanshah, Iran

Armin Zarinkhat

Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

Nasim Akhshi

Department of Anatomical Sciences, Kermanshah University of Medical Sciences, School of Medicine, Kermanshah, Iran