Intra-periaqueductal Grey Matter Injection of Orexin A Attenuates Nitroglycerin-induced Deficits in Learning and Memory in Male Rats
Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
View: 58
This Paper With 10 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_IJVST-15-2_006
تاریخ نمایه سازی: 24 تیر 1402
Abstract:
This study explored the potential contribution of Orx۱R within vlPAG to the learning and memory of animals with chronic migraine-like pain. Migraine was induced by repeated i.p. administration of nitroglycerin (۵ mg/kg). Passive avoidance adeptness was evaluated in the shuttle box maze. The spatial memory performance was estimated using MWM tests. In the MWM task, NTG-injected rats revealed an imperative increase in escape latency and traveled the distance to catch the stage and a decrease in the time spent to pass into the goal zone in comparison to the control animals. Such NTG-evoked responses were attenuated by the post-treating intra-vlPAG injection of orexin A at ۱۰۰ but not ۲۵ and ۵۰ pM. Furthermore, in the shuttle box test, NTG-treated rats showed eversion memory retrieval impairment as reflected by decreased phase through latency and longer time spent in the black chambers of the maze. Administration of orexin A at ۵۰ and ۱۰۰ pM could suppress NTG-related eversion memory deficiency in rats. However, orexin A (۱۰۰ pM) aptitude to preserve memory performance, in both MWM and shuttle box tasks, was significantly prevented by SB۳۳۴۸۶۷ (۲۰ nM) as an Orx۱R antagonist. Overall, these data support the role of Orx۱R within vlPAG to modulate migraine-related cognition deficits in rats.
Keywords:
Authors
Razieh Kooshki
Department of Biology, Faculty of Science, Lorestan University, Khorramabad, Iran.
Mehdi Abbasnejad
Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran.
Baharosadat Majdzadeh
Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran.
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :