Diagnostic Strategies for Early Detection of Oral Squamous Cell Carcinoma: A Review Article
Publish place: Avicenna Journal of Dental Research، Vol: 14، Issue: 3
Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_AJDR-14-3_005
تاریخ نمایه سازی: 28 تیر 1402
Abstract:
Background: Oral squamous cell carcinoma (OSCC) is the sixth most common cancer with high morbidity
and mortality rates. Late diagnosis and high incidence rate of OSCC have become global healthcare issues.
The purpose of this review was to provide an overview of the diagnostic and prognostic biomarkers in
OSCC.
Methods: A literature search in PubMed, ScienceDirect, and Google Scholar was performed. The keywords
“early detection”, “oral cancer”, and “oral squamous cell carcinoma” were searched in the title and
abstract of the articles published in English from ۲۰۰۰ to mid-۲۰۲۱. The full texts of ۲۵۰ articles were
retrieved and only ۶۳ articles met the inclusion criteria.
Results: In summary, all selected papers discussed the importance of early detection along with different
factors and techniques to detect oral cancer. The biomarkers were divided into three groups as follows:
salivary biomarkers, circulating biomarkers, and tissue biomarkers.
Conclusions: In this review article, salivary biomarkers along with the circulating and tissue biomarkers
were reviewed. Besides, some detection techniques were explained.
Keywords:
Authors
Soussan Irani
Associate Professor, Dental Research Centre, Oral Pathology Department, Dental Faculty, Hamadan University of Medical Sciences, Hamadan, Iran