Acute Effect of Concurrent Exercise on Serum Leptin and Resistance Insulin Response in Sedentary Men

This study aimed to determine the delayed effect of one session of concurrent exercise on serum leptin and resistance insulin levels of sedentary men. Materials and Methods: Fifteen healthy young men with a mean age of ۲۲.۹ ± ۱.۷ years and a body mass index of ۲۳.۳ ± ۱ kg/m۲ voluntarily participated in this experimental research. They participated in one session of concurrent exercise including ۲۰ min of aerobic running on a treadmill at ۶۰%–۷۰% maximum oxygen uptake plus a resistance exercise at the intensity of ۷۰% of ۱‑repetition maximum with ten repetitions per set to second round. Blood serum leptin, glucose, insulin, and insulin resistance index were assessed before, ۲۴, ۴۸, and ۷۲ h after the exercise program. Results: The results showed that leptin level did not change statistically significantly immediately and ۷۲ h after the exercise termination (P > ۰.۰۵) but did decrease statistically significantly ۲۴ and ۴۸ h after the exercise program (P ≤ ۰.۰۵). The result also showed that insulin and insulin resistance levels decreased statistically significantly immediately after the exercise and lasted for up to ۴۸ h postexercise (P ≤ ۰.۰۵); however, it returned to its initial value after ۷۲ h of recovery (P > ۰.۰۵). Conclusions: It was concluded that energy use in one session of concurrent exercise might reduce leptin levels up to ۴۸ h of recovery. In addition, a decrease in insulin, a known inducer of leptin expression in adipocytes, occurs before the decrease in leptin. This change may mediate the decrease of leptin concentration.

Keywords:

Exercise , insulin resistance , leptin