The effect of eight weeks of interval training and quercetin nanoliposome supplementation on NF-κB and FGF-۲ gene expression in the heart tissue of myocardial infarction rats
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نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_SKUMS-24-1_005
تاریخ نمایه سازی: 31 تیر 1402
Abstract:
Background and aims: The activation of inflammatory reactions is essential immediately after the onset of myocardial infarction (MI). On
the other hand, the path of inflammatory activators should be controlled to prevent the recurrence of MI. In this vein, the aim of this study
was to examine the effect of eight weeks of interval training and quercetin nanoliposome consumption on nuclear factor kappa B (NF-κB)
and fibroblast growth factor ۲ (FGF-۲) gene expression in the heart tissue of MI rats.
Methods: In this experimental study, ۳۰ male rats, aged approximately ۶-۸ weeks, were randomly divided into five groups including MI
+ training, MI + supplement, MI + training + supplement, healthy control, and MI. The MI was induced by the subcutaneous injection of
isoprenaline hydrochloride at a dose of ۸۰ mg/kg. Quercetin was daily administered at a dose of ۰.۲۵ mg for ۸ weeks, and interval training
was performed ۵ days a week. NF-κB and FGF-۲ gene expressions were measured by the real-time polymerase chain reaction. Finally, data
were analyzed using the one-way analysis of variance (ANOVA) and Tukey’s post hoc tests (P < ۰.۰۵).
Results: Training significantly increased NF-κB gene expression in the MI+ training, MI + supplement, and MI + training + supplement
groups (P = ۰.۰۰۱) while significantly decreasing FGF-۲ gene expression in the MI group (P = ۰.۰۴).
Conclusion: Interval training may prevent the negative effects of MI by reducing pro-inflammatory gene expression in the heart tissue,
leading to improved cardiovascular function and the prevention of this disease.
Keywords:
High-intensity interval training , Nuclear factor kappa B , Fibroblast growth factor-۲ , Quercetin supplementation , Myocardial
infarction
Authors
Samira Zaheri Abdehvand
PhD Student, Department of Physical Education and Sport Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran
Khosro Jalali Dehkordi
Assistant Professor, Department of Physical Education and Sport Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran
Farzaneh Taghian
Assistant Professor, Department of Physical Education and Sport Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran