Protective effect of Vitamin E against Glyphosate-induced Reproductive failure in Female Rats
Publish place: Journal of Advanced Biomedical Sciences، Vol: 11، Issue: 3
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
View: 60
This Paper With 10 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_JABS-11-3_005
تاریخ نمایه سازی: 31 تیر 1402
Abstract:
Background & Objective: The glyphosate-based herbicide has a prominent role in the toxic mechanism in living systems. Previous studies have shown that vitamin E can have a protective effect on cells against oxidative damage. This study aimed to evaluate the protective effect of vitamin E against the toxic potential of glyphosate (Gly) in the reproductive system of female rats.
Materials & Methods: In this experimental study, ۳۰ female Wistar rats were randomly divided into five groups (n=۶), including control, glyphosate (۵۰ mg/kg per day), glyphosate (۵۰۰ mg/kg per day), glyphosate (۵۰ mg/kg per day) + vitamin E (۵۰ mg/kg per day), and glyphosate (۵۰۰ mg/kg per day) + vitamin E (۵۰ mg/kg per day). Glyphosate was administered orally, and vitamin E was administered by intraperitoneal injection. After ۳۵ days, rats were euthanized, and embryo development, malondialdehyde (MDA) concentration, and catalase (CAT) activity were examined. Moreover, the levels of estrogen and progesterone were measured in the serum. Results were analyzed by SPSS software using one-way ANOVA and Tukey’s post hoc test.
Results: The glyphosate significantly decreased the percentages of fertilization, two-cell embryos, blastocysts, estrogen, and progesterone level as well as catalase activity and significantly increased MDA level in glyphosate-treated rats in comparison with controls (p<۰.۰۵). However, the results showed that vitamin E can reduce the toxicity of glyphosate administration in the mentioned parameters (p> ۰.۰۵).
Conclusion: These results have shown that vitamin E can provide the antioxidant defense with potent preventive activity against glyphosate-induced reproductive toxicities.
Keywords:
Authors
پرستو حیدری
Department of Biology, Faculty of Science, Urmia University, Urmia, Iran
فرح فرخی
Department of Biology, Faculty of Science, Urmia University, Urmia, Iran
غلامرضا نجفی
Department of Veterinary Medicine, Faculty of Basic Sciences, Urmia University, Urmia, Iran
عباس صادقی
Department of Veterinary Medicine, Faculty of Basic Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :