Role of miR-۱۴۶a in Immune System and Autoimmunity
Publish Year: 1395
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JIML-3-3_001
تاریخ نمایه سازی: 14 مرداد 1402
Abstract:
MicroRNAs (miRNAs) are small preserved non-coding RNA molecules that regulate gene expression post-transcriptionally by targeting the ۳' UTR of mRNAs for translational repression or degradation. The rising evidence has established the significant role of miRNAs within the regulation of immune system and the prevention of autoimmunity. MiR-۱۴۶a has obtained an importance as a modulator of differentiation and the function of cells of the adaptive, as well as innate immunity rapidly. In this paper, we summarize the recent understanding of the role of miR-۱۴۶a in adaptive and innate immune responses, as well as in autoimmunity.
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Authors
Bahram Moghimi
Department of Genetics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Saba Gharibi
Department of Genetics, Faculty of Medicine, International Campus, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Ehsan Farashahi Yazd
Department of Genetics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mohammad Taher Tahoori
Department of Immunology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Seyed Mehdi Kalantar
Department of Genetics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
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