Evaluation of antibacterial effects of silver nanoparticles with thiazole, imidazole and tetrahydropyridine derivatives against hospital gram negative bacterial pathogens

Background and Aim: Silver nanoparticles, thiazole, imidazole and tetrahydropyridine derivatives are all new antibacterial compounds that detection and comparison of their antibacterial effects can help to the selection of alternative antibiotics’ combinations against resistant bacterial strains especially gram- negative pathogenic bacteria in hospitals. In this regard, the aim of this study was comparison of antibacterial effects of silver nanoparticles, thiazole, imidazole and tetrahydropyridine derivatives on three gram -negative bacteria including Proteus mirabilis, Acinetobacter baumannii and Shigella dysenteriae. Materials and Methods: To evaluate the antibacterial effects, the disk diffusion method was applied to measure the growth inhibition zone diameter and broth microdilution was performed to determine the minimum inhibitory concentration (MIC). Results: The results showed that thiazole, imidazole and tetrahydropyridine derivatives as well as silver nanoparticles had no inhibitory effect on A. baumannii. There was also no inhibitory effect from imidazole and tetrahydropyridine compounds besides ۶a-c derivative of thiazole on bacteria. In this study, the inhibitory growth zone diameter of ۱۷.۳ and ۱۸.۵ was recorded for the inhibitory effect of the ۶d derivative of thiazole on P. mirabilis and S. dysenteriae mm and MIC of ۱۲۵ and ۶۲.۵ µg/ml for them, respectively. Furthermore, the silver nanoparticle had inhibitory effect with inhibitory growth zone diameter of ۱۳.۴ and ۱۵.۲ mm and MIC of ۱۱۲۵ and ۵۶۲.۵ µg/ml on P. mirabilis and S. dysenteriae, respectively. Conclusions: In this study the antibacterial potency of thiazole derivative was proved in comparison to the silver nanoparticle.

Keywords:

Antibacterial effect , Silver nanoparticles , Thiazole , Iimidazoline , Tetrahydropyridine derivatives , اثرات ضد باکتریایی , نانو ذرات نقره , مشتقات تیازول , ایمیدازول و تتراهیدروپیریدین