Brønsted Acidic Ionic Liquid: An Efficient and ReusableCatalyst for the Multi-Component Synthesis ofDihydropyrimidinones under Solvent-Free Conditions

An efficient and convenient procedure for the synthesis of ۳,۴-dihydropyrimidin-۲(۱H)-ones and thiones by condensation of ۱,۳-dicarbonylcompounds, Aromatic and aliphatic aldehydes, and urea or thiourea in the presence ofcatalytic amount of Brønsted acidic ionic liquid ۳-methyl-۱-sulfonic acid imidazoliumchloride {[Msim]Cl} under thermal solvent-free conditions reacted easily to afford thecorresponding ۳,۴-dihydropyrimidin-۲(۱H)-ones and thiones. Straightforward andclean workup, short reaction time, good to excellent yields and reusability of thecatalyst are the advantages of this method.

Keywords:

Dihydropyrimidinone , Ionic liquid , Brønsted acidic , reusable catalyst , thiourea