Catalyst-Free One-Pot Four-Component Synthesis of ۳-(Imino)-pyrrolo[۲,۱-a]isoquinolines in Glycerol: Two Different Products through Two Different Purification Methods
Publish place: Organic Chemistry Research، Vol: 6، Issue: 1
Publish Year: 1399
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_ORGC-6-1_002
تاریخ نمایه سازی: 3 مهر 1402
Abstract:
The one-pot four component synthesis of ۳-(Imino)-۲,۳-dihydropyrrolo[۲,۱-a]isoquinoline-۱,۱(۱۰bH)-dicarbonitrile derivatives via a catalyst-free reaction between aryl aldehydes, malononitrile, isoquinoline and isocyanides was successfully conducted in glycerol as a benign, nontoxic and biodegradable promoting reaction medium. The progress of the reaction with two different common purification methods were investigated. Moreover, synthesized products were examined as chemical sensors for the detection of a wide range of metal ions and it was successful for the detection of Co۲+ ions.
Keywords:
Multicomponent synthesis , In column chromatography reaction , Glycerol , Sustainable reaction medium , Isocyanide
Authors
Seyed Ali Jehbez
Department of Applied Chemistry, Shiraz Branch, Islamic Azad University, P.O. Box ۷۱۹۹۳-۵, Shiraz, Iran
Hamidreza Safaei
Department of Applied Chemistry, Shiraz Branch, Islamic Azad University, P.O. Box ۷۱۹۹۳-۵, Shiraz, Iran
Mohsen Shekouhy
Chemistry Department, College of Sciences, Shiraz University, Shiraz, Iran