Evaluation of the Effect of Capparis spinosa L. on Cisplatin-Induced Liver Injury in Male Rats based on Persian Medicine

Background and Objective: Cisplatin as a chemotherapy drug causes liver damage by increasing inflammation. Hepatoprotective agents with antioxidant properties can be useful for preventing this complication. Capparis spinosa, as a natural antioxidant source, can help to eliminate these productions. The purpose of this study was to determine the effect of two different doses of hydroalcoholic extract of Capparis seed on cisplatin-induced liver damages in rats. Materials and Methods: Forty male rats were divided into five groups (the control group, Cis (cisplatin) group, ۲۰۰ C/S (Capparis spinosa), Cis + ۵۰ C/S, and Cis + ۱۰۰ C/S). Biochemical and histopathological evaluations were made. At the end of the study, all animals were euthanized with a CO۲ gradient. Statistical analyses were performed through Graph Pad Prism Statistics software ۹.۱.۲. The level of significance was set at p < ۰.۰۵. Results: Liver function tests, antioxidant and inflammatory markers and histopathological changes were evaluated. Significant changes in the pathology results were noticeable. Central vein, portal vein and bile duct diameter, thickness of the hepatic artery wall, and hepatic sinusoids were significantly increased in the Cis and ۲۰۰ C/S-fed groups, compared to the controls, and also changes in favor of improvement were evident in the treatment groups, especially in the Cis + ۱۰۰ C/S group compared to the Cis and ۲۰۰ C/S groups. Conclusion: Based on pathology results, treatment with C. spinosa seed extract may be helpful in preventing cisplatin hepatotoxicity.

Keywords:

Drug-Induced Liver Injury , Capparis spinosa L. , Cisplatin , Medicine , Persian