Novel Fracture Improvements via Vitamin D Supplementation

Background: Distal radius fracture (DRF) is one of the most common upper limb fractures, which is associated with osteoporosis and vitamin D deficiency, especially in old adults.Objectives: The aimof this studywas to evaluate the effectof supplementary vitaminDongrip strength, pinchpower, painintensity, and DASH score in post-menopausal females after distal radius fractures.Methods: Fifty-two post-menopausal women with distal radius fractures were enrolled in a randomized single-blinded multicenter trial from January ۲۰۱۵ to January ۲۰۱۶ (IRCT registration number: IRCT۲۰۱۶۰۸۳۰۰۲۹۶۰۳N۷). Patients with pre-operative serum vitamin D level of ۳۰ to ۱۰۰ ng/mL were enrolled in the study. Patients were divided into two randomized groups including groups with and without supplementation of vitamin D [۲۵ women in intervention group (۵۰,۰۰۰ IU supplementary vitamin D, every ۴ weeks for ۶ months) and ۲۷ women in placebo group]. Grip strength, pinch power, pain intensity, and DASH score pre-operatively and at three and six months after the surgery were measured; the obtained data were analyzed using SPSS version ۱۶.Results: The subjects’ mean age in vitamin D supplemented and placebo group was ۵۷.۹۸ ± ۷.۱۵ and ۵۹.۱۵ ± ۸.۰۳, respectively. The mean grip strength of patients in vitamin D supplemented group was significantly higher than the placebo group on both the third and sixth months (P = ۰.۰۱۱ and P = ۰.۰۰۳, respectively). The pinch power was significantly increased on the sixth month compared to the third month in patients with revised vitamin D supplementation (۱.۳۲ ± ۲.۱۴ and ۰.۶۷ ± ۰.۹۶ respectively, P = ۰.۰۰۰۱). There was no statistically significant difference between the two groups in terms of mean VAS and DASH scores at the end of the study (P = ۲۴۱, P = ۰.۶۶۵, respectively).Conclusions: Vitamin D supplementation was significantly helpful in improving grip strength recovery in post-menopausal women after distal radius fracture, however, no significant differences were observed in supplementation of vitamin D on pinchpower and pain intensity after distal radius fractures.

Keywords:

Vitamin D , Distal Radius , fracture , Post-Menopausal , Wrist Function