سیویلیکا را در شبکه های اجتماعی دنبال نمایید.

Effect of Exercise Training on Tropomodulin-2 Gene Expression in Cerebellum of Diabetic Rats

Publish Year: 1397
Type: Journal paper
Language: English
View: 112

This Paper With 10 Page And PDF Format Ready To Download

Export:

Link to this Paper:

Document National Code:

JR_IJDO-11-1_006

Index date: 7 November 2023

Effect of Exercise Training on Tropomodulin-2 Gene Expression in Cerebellum of Diabetic Rats abstract

Objective: It is well documented that exercise training (ET) imposes beneficial effects on diabetes mellitus and its complication such as diabetic peripheral neuropathy (DPN). Regarding the importance of tropomodulin-2 (TMOD2) in nervous system plasticity, this protein may be recognized as a candidate mechanism for ET-induced neuroplasticity. The aim of this study was to investigate the effects of ET on cerebellar gene expression of TMOD2 in rats with DPN. Materials and Methods: Animals were randomly divided into three groups: healthy control (C), diabetic control (DC) and diabetic trained (DT). Diabetes was induced by a single intraperitoneal injection of streptozotocin. Behavioral nociception assessment was carried out by Von Frey Filaments and tail-flick tests. TMOD2 gene expression was assessed by real time-PCR. Results: The mRNA levels of TMOD2 increased to 0.50-fold (P-value: 0.005) in comparison of the sedentary controls after 6 weeks of DPN. Also, TMOD2 gene expression in DT group was decreased to -0.68-fold changes in comparison of the C group (P-value: 0.001). In addition, the TMOD2 gene expression in DT group was lower than the DC group (P-value: 0.0001). Conclusion: The TMOD2 mRNA level in rat’s cerebellum was affected by ET and DPN, but its exact physiological roles were not clarified. Hence, identifying the importance of TMOD2 in DPN needs further research.

Effect of Exercise Training on Tropomodulin-2 Gene Expression in Cerebellum of Diabetic Rats Keywords:

Effect of Exercise Training on Tropomodulin-2 Gene Expression in Cerebellum of Diabetic Rats authors

Seyed Jalal Taherabadi

Department of Sport Sciences, Lorestan University, Khoram Abad, Iran.

Masoud Rahmati

Department of Sport Sciences, Lorestan University, Khoram Abad, Iran.

Rahim Mirnasuri

Department of Sport Sciences, Lorestan University, Khoram Abad, Iran.

Abdolreza Kazemi

Department of Sport Sciences, Vali-E-Asr University of Rafsanjan, Kerman, Iran.

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :
Liu J, Feng L, Ma D, Zhang M, Gu J, ...
Mooradian AD. Diabetic complications of the central nervous system. Endocrine ...
Pop-Busui R, Boulton AJ, Feldman EL, Bril V, Freeman R, ...
Gomez TM, Letourneau PC. Actin dynamics in growth cone motility ...
Kronenberg G, Gertz K, Baldinger T, Kirste I, Eckart S, ...
Yamashiro S, Gokhin DS, Kimura S, Nowak RB, Fowler VM. ...
Cox PR, Fowler V, Xu B, Sweatt JD, Paylor R, ...
Moroz N, Guillaud L, Desai B, Kostyukova AS. Mutations changing ...
Gray KT, Suchowerska AK, Bland T, Colpan M, Wayman G, ...
Sun Y, Dierssen M, Toran N, Pollak DD, Chen W-Q, ...
Yang J, Czech T, Felizardo M, Baumgartner C, Lubec G. ...
Fulga TA, Elson-Schwab I, Khurana V, Steinhilb ML, Spires TL, ...
Benitez-King G, Ramirez-Rodriguez G, Ortiz L, Meza I. The neuronal ...
Sowani A. Diabetes Mellitus and Brain. ECAB Reviews in Neurology ...
Ji L, Zhang H, Potter GG, Zang Y-F, Steffens DC, ...
Cotman CW, Berchtold NC, Christie L-A. Exercise builds brain health: ...
Hötting K, Röder B. Beneficial effects of physical exercise on ...
Petzinger GM, Fisher BE, McEwen S, Beeler JA, Walsh JP, ...
Reddemma Sandireddy VGY, Areti A, Komirishetty P, Kumar A. Neuroinflammation ...
Codella R, Lanzoni G, Zoso A, Caumo A, Montesano A, ...
Chae C-H, Kim H-T. Forced, moderate-intensity treadmill exercise suppresses apoptosis ...
Calcutt NA. Modeling diabetic sensory neuropathy in rats. Pain Research: ...
Fox A, Eastwood C, Gentry C, Manning D, Urban L. ...
Kohler I, Meier R, Busato A, Neiger-Aeschbacher G, Schatzmann U. ...
Wang H, Sun H, Della Penna K, Benz R, Xu ...
Jellinger KA. Recent advances in our understanding of neurodegeneration. Journal ...
Fath T, Fischer RS, Dehmelt L, Halpain S, Fowler VM. ...
Represa A, Tremblay E, Ben-Ari Y. Sprouting of mossy fibers ...
Kumar TP, Paul J, Antony S, Paulose C. Expression of ...
Rahmati M, Gharakhanlou R, Movahedin M, Mowla S, Khazani A, ...
Ströhle A, Schmidt DK, Schultz F, Fricke N, Staden T, ...
Singleton JR, Smith AG, Marcus RL. Exercise as Therapy for ...
Trejo JL, Carro E, Torres-Alemán I. Circulating insulin-like growth factor ...
Van Praag H, Christie BR, Sejnowski TJ, Gage FH. Running ...
Kim H-B, Jang M-H, Shin M-C, Lim B-V, Kim Y-P, ...
Rahmati M, Gharakhanlou R, Movahedin M, Mowla SJ, Khazani A, ...
Richter EA, Garetto LP, Goodman MN, Ruderman NB. Muscle glucose ...
Peres SB, de Moraes SMF, Costa CE, Brito LC, Takada ...
Knaepen K, Goekint M, Heyman EM, Meeusen R. Neuroplasticity—exercise-induced response ...
Ford ES. Does exercise reduce inflammation? Physical activity and C-reactive ...
Kluding PM, Pasnoor M, Singh R, Jernigan S, Farmer K, ...
Taherabadi SJ, Heidarianpour A, Basereh M. Effects of Submaximal Endurance ...
Chen Y-W, Hsieh P-L, Chen Y-C, Hung C-H, Cheng J-T. ...
Shankarappa SA, Piedras‐Rentería ES, Stubbs EB. Forced‐exercise delays neuropathic pain ...
Cobianchi S, Casals-Diaz L, Jaramillo J, Navarro X. Differential effects ...
Rossi DM, Valenti VE, Navega MT. Exercise training attenuates acute ...
Koltyn KF. Analgesia following exercise. Sports medicine. ۲۰۰۰;۲۹(۲):۸۵-۹۸ ...
Peeyush KT, Gireesh G, Jobin M, Paulose C. Neuroprotective role ...
Arantes LM, Bertolini NO, de Moura RF, de Mello MAR, ...
Hernández-Fonseca JP, Rincón J, Pedreañez A, Viera N, Arcaya JL, ...
نمایش کامل مراجع