The Association between GNB۳ Gene Polymorphism and Obesity: A Systematic Review and Meta-Analysis
Publish place: Iranian Journal of Diabetes and Obesity، Vol: 9، Issue: 1
Publish Year: 1396
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJDO-9-1_011
تاریخ نمایه سازی: 16 آبان 1402
Abstract:
The association between Guanine Nucleotide Binding protein β protein polypeptide ۳(GNB۳) C۸۲۵T polymorphism and obesity has recently been reported. However, the findings remain inconclusive. The aim of this systematic review and meta-analysis was to detect the relationship between GNB۳ C۸۲۵T polymorphism and obesity.
Materials and Methods: Six electronic databases including Embase, Medline, science direct and SID were investigated and searched for English articles, published before February ۲۰۱۶, which referred to the association between GNB۳ C۸۲۵T polymorphism and obesity. Pooled odds ratios (OR) with a ۹۵% confidence interval (CI) were calculated in allele, recessive, dominant and additive genetic models to assess this association.
Results: The findings demonstrated that GNB۳ TT homozygote status was significantly associated with an increased risk of obesity compared with CC wild-type homozygote (TT vs. CC: OR= ۱.۲۳۷, ۹۵% CI: ۱.۰۴۰- ۱.۴۷۲, P-value:۰.۰۱۶), while one mutation allele (TC) could not significantly increase the risk of obesity (TC vs. CC: OR= ۰.۹۱, ۹۵% CI: ۰.۷۹- ۱.۰۵, P-value:۰.۲۰۷).
Conclusion: Our meta-analysis suggested a significant association between the TT genotype of the GNB۳ gene polymorphism and obesity risk. Thus, targeted healthcare should be strengthened with regard to this gene carrier in order to prevent obesity.
Keywords:
Authors
Narges Faramarziyan
Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran.
Masoud Rahmati
Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran.
Rahim Mirnasouri
Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran.
Mostafa Bahrami
Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran.
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