Protein ۵۳ expression in a mixed Labrador subcutaneous lymphoma
Publish place: Veterinary Research Forum، Vol: 3، Issue: 2
Publish Year: 1391
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_VRFAN-3-2_012
تاریخ نمایه سازی: 25 آبان 1402
Abstract:
An ۱۱ year – old mixed female Labrador was presented with two masses in trunk and neck. The tumoral masses were excised and sent for histopathological and immunohistochemical analyses. Histopathological examination of masses revealed diffuse infiltration of small sized lymphoid cells in subcutaneous tissue which were intense around the blood vessels. More than ۱۰% lymphoid cells were CD۳ positive in the immunohistochemical staining and most of them were accumulated around vessels. Protein ۵۳ (p۵۳) expression was detected by brown nuclei in immunohistochemical staining. Subcutaneous lymphoma was diagnosed according to histopathological results. After ۶ months the case was referred with multicentric lymphoma and based on the owner request euthanasia was performed. These findings emphasize on poor prognosis for tumors with p۵۳ mutation.
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Authors
Annahita Rezaie
Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
Abbas Tavassoli
Department of Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran