The histological and histometrical effects of Urtica dioica extract on rat’s prostate hyperplasia
Publish place: Veterinary Research Forum، Vol: 6، Issue: 1
Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_VRFAN-6-1_004
تاریخ نمایه سازی: 25 آبان 1402
Abstract:
Benign prostatic hyperplasia (BPH) is a common disease in human that gradual overgrowth of the prostate gland leads to impinge on the urethra with impairment in urinary function. Numerous plants improve uncontrolled growth of the prostate gland and improve urinary tract symptoms associated with BPH. In this study, ۲۵ healthy adult male Wistar rats were divided randomly in five groups: G۱ (Control group) received ordinary feed without any treatment, G۲ received ۱۰ mg kg-۱ testosterone subcutaneously, G۳ received ۵۰ mg kg-۱ nettle root extract orally, G۴ received ۵۰ mg kg-۱ nettle root extract orally and ۱۰ mg kg-۱ testosterone, G۵ received ۱۰ mg kg-۱ almond oil (Almond oil was used as testosterone solvent) subcutaneously. After six weeks, volume and weight of each lobe were measured and samples were taken. The ۵ to ۶ µm thickness sections were made using paraffin embedding method and stained by hematoxylin and eosin and periodic acid-Schiff. The results showed that prostate volume and ratio of prostate to body weight were increased significantly in the testosterone. Histological and histometrical results showed that dorsal and lateral type ۱ and ۲ lobes were not changed significantly but the ventral and anterior lobes have changed significantly. Over all, the nettle root could prevent from some of prostatic hyperplasia effects, so that percentage of folded alveoli in ventral lobe reduced insignificantly.
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Authors
Hamid Reza Moradi
Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
Naeem Erfani Majd
Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
Saleh Esmaeilzadeh
Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
Sayed Reza Fatemi Tabatabaei
Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
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