Exploring the main effects of Phoenix dactylifera on destructive changes caused by cyclophosphamide in male reproductive system in mice
Publish place: Veterinary Research Forum، Vol: 13، Issue: 2
Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_VRFAN-13-2_014
تاریخ نمایه سازی: 25 آبان 1402
Abstract:
Cyclophosphamide leaves an undesirable effect on testes. This study was conducted to explore the effects of the Phoenix dactylifera (DP) on testes following the cyclophosphamide treatment. Thirty-six male mice were divided into six groups, one control, one cyclophosphamide, two groups of cyclophosphamide with a dose of ۲۰۰ mg kg-۱ and a dose of ۴۰۰ mg kg-۱ DP, and two of only high and low doses of DP. All groups were gavaged daily for ۲۸ days. The animals were euthanized ۲۴ hr after implementing the last treatment. Then, the testes and epididymis samples were removed and weighed. The main sperm characteristics such as the number of sperm and sperm viability, the morphometric changes, biochemical analysis of testes and enzyme activity were investigated. With the cyclophosphamide group, only body weight, testes weight, epididymis weight, sperm viability and the fertilization percentage were decreased significantly compared to the control group. Moreover, the spermatogenesis indices and morphometric parameters in this group indicated a significant decrease. Furthermore, the morphological changes were observed in the testicular tissue, including seminiferous tubule atrophy, vacuolation, hyperemia of blood vessels and increased space in the interstitial tissue. In the biochemical study of cyclophosphamide group, the amount of glutathione peroxidase in serum was decreased, whereas, the amount of malondialdehyde in testicular tissue showed a significant increase. The DP group included the antioxidant and anti-apoptotic properties. It seemed that the compounds in the DP would lead to the inhibition of the production of active metabolites released from the cyclophosphamide.
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Authors
Narges Delgarm
MSC Student of Developmental Biology, Department of Basic Science, Faculty of Veterinary Medicine, Ardakan University, Ardakan, Iran
Majid Morovati Sharifabad
Department of Basic Sciences, Faculty of Veterinary Medicine, Ardakan University, Ardakan, Iran
Elham Salehi
Department of Basic Sciences, Faculty of Veterinary Medicine, Ardakan University, Ardakan, Iran
Mohammad Afkhami-Ardakani
Phd Graduate of Histology, Department of Basic Science, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Mohammad Saeed Heydarnejad
Department of Animal Sciences, Faculty of Basic Sciences, Shahrekord University, Shahrekord, Iran
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