Value of TOX Immunoexpression in the Diagnosis of Early Mycosis Fungoides
Publish place: Middle East Journal of Cancer، Vol: 10، Issue: 2
Publish Year: 1398
Type: Journal paper
Language: English
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Document National Code:
JR_MISJ-10-2_003
Index date: 16 November 2023
Value of TOX Immunoexpression in the Diagnosis of Early Mycosis Fungoides abstract
Background: The lack of a specific marker to differentiate malignant from reactiveT-cells makes a definite diagnosis difficult in patients suspected of having mycosisfungoides. This study has evaluated value of thymocyte selection-associated highmobility group box factor expression in the differentiation of early mycosis fungoidesfrom a benign inflammatory dermatosis.Methods:We selected 22 mycosis fungoides cases, 18 cases suspicious for mycosisfungoides, and 12 cases of eczematous dermatitis from patients who attendedDermatology Clinic, Shiraz University of Medical Sciences (2008-2015). The obtainedskin biopsies were immunostained for thymocyte selection-associated high mobilitygroup box factor antigen in addition to pan T cell markers. The slides were evaluatedfor the percentage of tumor cells and intensity of immunoreactivity.Results: From 22 cases of mycosis fungoides, 40.9% showed massive infiltrationof thymocyte selection-associated high mobility group box factor-positive lymphocytes(>30%) with high (3+) intensity in the epidermis; there was no case negative forthymocyte selection-associated high mobility group box factor expression. Only oneeczematous dermatitis case had expression of thymocyte selection-associated highmobility group box factor-positive lymphocytes (>30%) with high intensity and 4 caseswere negative for thymocyte selection-associated high mobility group box factorexpression. The frequency of thymocyte selection-associated high mobility groupbox factor expressing lymphocytes was higher in biopsies from mycosis fungoidescompared to eczematous dermatitis (P<0.05). CD7- cases expressed more thymocyteselection-associated high mobility group box factor-positive lymphocytes in the dermisand epidermis, which were significantly correlated (P=0.013).Conclusion: Thymocyte selection-associated high mobility group box factor, as apositive marker, in combination with pan T cell markers (especially CD7-) can be usefulto detect mycosis fungoides malignant lymphoid cells.
Value of TOX Immunoexpression in the Diagnosis of Early Mycosis Fungoides Keywords:
Value of TOX Immunoexpression in the Diagnosis of Early Mycosis Fungoides authors
Fatemeh Sari Aslani
Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Akbar Safaei
Pathology Department, Shiraz University of Medical Sciences, Shiraz, Iran
Hale Ghezelbash
Pathology Department, Shiraz University of Medical Sciences, Shiraz, Iran
Mozhdeh Sepaskhah
Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran