Effect of Zinc Sulfate on Overall Survival and Progression-Free Survival in Patients with Glioblastoma Multiforme, a Phase II Study

Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_MISJ-14-1_011

تاریخ نمایه سازی: 25 آبان 1402

Abstract:

Background: Glioblastoma is the most prevalent and aggressive adult glial tumor. Patients who receive standard treatment have a mean survival of ۱۲-۱۴ months. Zinc is a micronutrient that has shown to have anticancerous effects. In the in vitro studies zinc had antineoplastic effects on gliobalstoma cells.Method: This is a phase II randomized trial in which ۶۰ patients in two groups were evaluated. The zinc group (۲۹ patients) received zinc sulfate supplement ۵۰ mg orally twice a day and the control group (۳۱ patients) who were selected from historical case sreceived no supplements.Results: Mean overall survival in the case and control groups were ۹.۹۳ (± ۳.۲۹) and ۹.۰ (± ۳.۵۶) months. In the case and control groups, the mean disease-free survival were ۹.۶۲ (SD ± ۳.۳۷) and ۸.۲۶ (SD ± ۳.۴۷) months. These differences were not statistically significant. Although overall survival and recurrence-free survival in patients in the case group was higher than the control group, there was no statistically significant difference (P = ۰.۴۸۵).Conclusion: Zinc consumption was associated with better survival, but these differences were not statistically significant, necessitating further studies.

Authors

Niloofar Ahmadloo

Radiation Oncology Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Parisa Kameli

Radiation Oncology Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Mansour Ansari

Breast Diseases Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Ahmad Mosalaei

Radiation Oncology Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Shapour Omidvari

Breast Diseases Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Hamid Nasrollahi

Radiation Oncology Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Seyed Hassan Hamedi

Radiation Oncology Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Mohammad Mohammadianpanah

Colorectal Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

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