A Comparison of Early Side-Effects of Short-Course and Long-Course Radiotherapy in Rectal Cancer

Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_MISJ-12-2_011

تاریخ نمایه سازی: 25 آبان 1402

Abstract:

Background: The variety of neoadjuvant treatments concerning rectal cancer has led to acute complications. The present study aimed to evaluate and compare the acute complications of short-course (SC) and long-course (LC) radiotherapy. Method: We studied ۱۰۰ patients suffering from rectal cancer, who referred to Nemazee Hospital before their surgery, in this cross-sectional study. The patients were divided into two categories: SC (۲۵ grays radiotherapy at ۵ fractions in ۵ days) and LC (chemoradiotherapy with a dose of ۴۵-۵۰.۴ grays in ۲۵- ۲۸ fraction in ۵-۶ weeks with concurrent Capecitabine (۸۲۵ mg / m۲) twice daily and five days a week). Subsequently, we evaluated them for acute complications in the SC group ۱۰-۱۴ days after the end of the treatment and in the LC group at intervals of the treatment, the end of it and ۲ weeks afterwards. Results: In the LC group compared to the SC group, the percentage of patients with grade ۱ diarrhea, grade ۲ colitis and grade ۱ cystitis at the end of the treatment was statistically different (p <۰.۰۰۱, P=۰.۰۴۶, P=۰.۰۳۶ ). In addition, the total number of the patients with grade ۱ and ۲ dermatitis was higher in the LC group compared with that in the SC group (P=۰.۰۴۶). We observed no significant differences between the two groups concerning the severe acute complications (P>۰.۰۵). Conclusion: This study implied that there were no significant differences regarding severe acute complication between the two groups.

Authors

Ahmad Mosalaei

Radiation Oncology Department, Shiraz University of Medical Sciences, Shiraz, Iran

Majdaddin Rajaei

Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran

Hamid Nasrollahi

Radiation Oncology Department, Shiraz University of Medical Sciences, Shiraz, Iran

Seyed Hassan Hamedi

Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran

Shapour Omidvari

Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Niloofar Ahmadloo

Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran

Mansour Ansari

Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Mohammad Mohammadianpanah

Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran