Primary Diffuse Large Cell Lymphoma of the Bladder: Case Report and Literature Review

Publish Year: 1396
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_MISJ-8-1_006

تاریخ نمایه سازی: 25 آبان 1402

Abstract:

Most bladder tumors are epithelial in origin. Nonepithelial cancers are rarely located in the bladder. Sarcomas are the most common malignancies among nonepithelial cancers. Primary bladder lymphoma is rare and mostly low grade. Here, we have reported a case of diffuse large cell lymphoma of the bladder. The patient, a ۶۴-year-old man, had urinary frequency for ۱۸ months. Abdominal sonography indicated a thick bladder wall and transurethral biopsy showed diffuse large cell lymphoma. Immunohistochemistry (IHC) results showed that the tumor was positive for CD۲۰, CD۴۵, and Pax-۵ and negative for BCL-۲, cytokeratin, and S۱۰۰. He had a normal bone marrow biopsy, abdominal, pelvic and chest CT scans. He had no B symptoms. The patient received ۶ cycles of R-CHOP followed by radiotherapy (۳۶ Gy) to the pelvis. Six months after treatment, the patient is well and has returned to work. We have searched PubMed for primary diffuse large cell lymphoma. Primary diffuse large cell lymphoma of the bladder is best treated according to treatment for diffuse large cell lymphoma of other sites, which includes chemotherapy and radiotherapy. As seen in our review, primary diffuse large cell lymphoma of the bladder has a similar clinical course to diffuse large cell lymphoma of other sites.

Authors

Mansour Ansari

Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Hamid Nasrollahi

Department of Radiation Oncology, Shiraz University of Medical Sciences, Shiraz, Iran

Majdaddin Rajaei

Department of Radiation Oncology, Shiraz University of Medical Sciences, Shiraz, Iran

Maral Mokhtari

Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran

Seyed Hasan Hamedi

Department of Radiation Oncology, Shiraz University of Medical Sciences, Shiraz, Iran

Mohammad Mohammadianpanah

Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Shapour Omidvari

Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Ahmad Mosalaei

Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran

Niloofar Ahmadloo

Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran